Drug interactions
Dronedarone + Irinotecan liposomal
Severity: Moderate
Dronedarone and Irinotecan liposomal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Irinotecan is activated to SN-38 and cleared in part by CYP3A4, with P-glycoprotein involved in its transport. Dronedarone may alter exposure to these species, which could change the balance of efficacy and toxicity such as neutropenia and diarrhea.
What this interaction means in plain words
Dronedarone and Irinotecan liposomal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4 and P-glycoprotein may alter irinotecan and SN-38 disposition.
What to do
Monitor blood counts and for severe diarrhea. Consider an alternative antiarrhythmic if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Dronedarone with Irinotecan liposomal?
MediHelp rates the interaction as moderate. Dronedarone and Irinotecan liposomal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Irinotecan is activated to SN-38 and cleared in part by CYP3A4, with P-glycoprotein involved in its transport. Dronedarone may alter exposure to these species, which could change the balance of efficacy and toxicity such as neutropenia and diarrhea.
How serious is the interaction between Dronedarone and Irinotecan liposomal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and for severe diarrhea. Consider an alternative antiarrhythmic if feasible.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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