Drug interactions
Dronedarone + Isoniazid
Severity: Moderate
Dronedarone and Isoniazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone is a CYP3A4 substrate that prolongs the QT interval, and isoniazid may increase its exposure. Higher levels could add to QT prolongation and bradycardia.
What this interaction means in plain words
Dronedarone and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronedarone belongs to Cardiovascular; Isoniazid belongs to Anti Bacterial.
Why it happens
Isoniazid inhibits CYP3A4, reducing dronedarone metabolism.
What to do
Check the ECG and monitor for bradycardia and QT prolongation. Consider an alternative if the QTc rises significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Dronedarone with Isoniazid?
MediHelp rates the interaction as moderate. Dronedarone and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone is a CYP3A4 substrate that prolongs the QT interval, and isoniazid may increase its exposure. Higher levels could add to QT prolongation and bradycardia.
How serious is the interaction between Dronedarone and Isoniazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check the ECG and monitor for bradycardia and QT prolongation. Consider an alternative if the QTc rises significantly.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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