Drug interactions
Dronedarone + Isradipine
Severity: Moderate
Dronedarone and Isradipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone is a moderate CYP3A4 inhibitor and can raise isradipine concentrations. It also has additive effects on heart rate and conduction with calcium channel blockers, so hypotension, bradycardia and AV block are possible.
What this interaction means in plain words
Dronedarone and Isradipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Dronedarone inhibits CYP3A4-mediated metabolism of isradipine, with additive pharmacodynamic effects on blood pressure and conduction.
What to do
Start isradipine at a low dose and titrate according to blood pressure. Monitor heart rate and ECG for bradycardia or conduction delay.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Dronedarone with Isradipine?
MediHelp rates the interaction as moderate. Dronedarone and Isradipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone is a moderate CYP3A4 inhibitor and can raise isradipine concentrations. It also has additive effects on heart rate and conduction with calcium channel blockers, so hypotension, bradycardia and AV block are possible.
How serious is the interaction between Dronedarone and Isradipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start isradipine at a low dose and titrate according to blood pressure. Monitor heart rate and ECG for bradycardia or conduction delay.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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