Drug interactions
Dronedarone + Ixabepilone
Severity: Moderate
Dronedarone and Ixabepilone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ixabepilone is cleared mainly by CYP3A4, and strong inhibitors markedly raise its exposure. Dronedarone is a moderate inhibitor and may increase ixabepilone toxicity such as neuropathy and neutropenia.
What this interaction means in plain words
Dronedarone and Ixabepilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4 reduces ixabepilone metabolism.
What to do
Monitor blood counts and neuropathy closely, and consider an alternative antiarrhythmic. Reduce the ixabepilone dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Dronedarone with Ixabepilone?
MediHelp rates the interaction as moderate. Dronedarone and Ixabepilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ixabepilone is cleared mainly by CYP3A4, and strong inhibitors markedly raise its exposure. Dronedarone is a moderate inhibitor and may increase ixabepilone toxicity such as neuropathy and neutropenia.
How serious is the interaction between Dronedarone and Ixabepilone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neuropathy closely, and consider an alternative antiarrhythmic. Reduce the ixabepilone dose if toxicity develops.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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