Drug interactions
Dronedarone + Mobocertinib
Severity: Major
Dronedarone and Mobocertinib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mobocertinib causes dose-related QT prolongation and is a CYP3A4 substrate, so dronedarone adds QT effects and raises mobocertinib concentrations. The combined effect substantially increases torsades de pointes risk.
What this interaction means in plain words
Dronedarone and Mobocertinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation plus CYP3A4 inhibition by dronedarone, increasing mobocertinib exposure.
What to do
Avoid the combination. If unavoidable, reduce the mobocertinib dose per labeling and monitor ECG and electrolytes frequently.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Dronedarone with Mobocertinib?
MediHelp rates the interaction as major. Dronedarone and Mobocertinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mobocertinib causes dose-related QT prolongation and is a CYP3A4 substrate, so dronedarone adds QT effects and raises mobocertinib concentrations. The combined effect substantially increases torsades de pointes risk.
How serious is the interaction between Dronedarone and Mobocertinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. If unavoidable, reduce the mobocertinib dose per labeling and monitor ECG and electrolytes frequently.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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