Drug interactions
Dronedarone + Neomycin po
Severity: Minor
Dronedarone and Neomycin po: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone inhibits P-glycoprotein and could modestly raise absorption of orally administered neomycin, which is normally very poorly absorbed. Any increase in systemic exposure is likely small, but neomycin carries nephrotoxic and ototoxic potential.
What this interaction means in plain words
Dronedarone and Neomycin po have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Dronedarone inhibits intestinal P-glycoprotein efflux of neomycin, potentially increasing its absorption.
What to do
No routine change is needed; monitor renal function and hearing if prolonged neomycin therapy is given, especially in patients with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dronedarone and Neomycin po, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Dronedarone with Neomycin po?
MediHelp rates the interaction as minor. Dronedarone and Neomycin po have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dronedarone inhibits P-glycoprotein and could modestly raise absorption of orally administered neomycin, which is normally very poorly absorbed. Any increase in systemic exposure is likely small, but neomycin carries nephrotoxic and ototoxic potential.
How serious is the interaction between Dronedarone and Neomycin po?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor renal function and hearing if prolonged neomycin therapy is given, especially in patients with renal impairment.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
