Drug interactions
Dronedarone + Nitrendipine
Severity: Moderate
Dronedarone and Nitrendipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone inhibits CYP3A4 and can increase nitrendipine exposure, enhancing its blood pressure lowering effect. Additive effects on heart rate and AV conduction may also occur.
What this interaction means in plain words
Dronedarone and Nitrendipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Dronedarone inhibits CYP3A4 metabolism of nitrendipine, with additive hemodynamic effects.
What to do
Begin with a low nitrendipine dose and monitor blood pressure and heart rate. Check ECG for conduction abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Dronedarone with Nitrendipine?
MediHelp rates the interaction as moderate. Dronedarone and Nitrendipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone inhibits CYP3A4 and can increase nitrendipine exposure, enhancing its blood pressure lowering effect. Additive effects on heart rate and AV conduction may also occur.
How serious is the interaction between Dronedarone and Nitrendipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Begin with a low nitrendipine dose and monitor blood pressure and heart rate. Check ECG for conduction abnormalities.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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