Drug interactions
Dronedarone + Olaparib
Severity: Moderate
Dronedarone and Olaparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone may raise olaparib exposure, increasing the risk of anemia, nausea and other adverse effects. Olaparib is cleared mainly by CYP3A4.
What this interaction means in plain words
Dronedarone and Olaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronedarone belongs to Cardiovascular; Olaparib belongs to Oncology.
Why it happens
Dronedarone inhibits CYP3A4, reducing olaparib metabolism.
What to do
If coadministration cannot be avoided, reduce the olaparib dose as stated in labeling and monitor blood counts.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Olaparib
- Amiodarone + Olaparib Major
- Amobarbital + Olaparib Major
- Apalutamide + Olaparib Major
- Aprepitant + Olaparib Major
- Azathioprine + Olaparib Major
- Carbamazepine + Olaparib Major
Frequently asked questions
Can I take Dronedarone with Olaparib?
MediHelp rates the interaction as moderate. Dronedarone and Olaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone may raise olaparib exposure, increasing the risk of anemia, nausea and other adverse effects. Olaparib is cleared mainly by CYP3A4.
How serious is the interaction between Dronedarone and Olaparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If coadministration cannot be avoided, reduce the olaparib dose as stated in labeling and monitor blood counts.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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