Drug interactions
Dronedarone + Olodaterol inhaled
Severity: Moderate
Dronedarone and Olodaterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone prolongs the QT interval and olodaterol, a long-acting beta2 agonist, can cause tachycardia, hypokalemia and QTc effects. Together they may raise the risk of ventricular arrhythmias, although systemic olodaterol exposure from inhalation is low.
What this interaction means in plain words
Dronedarone and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effects on cardiac repolarization and beta2-mediated hypokalemia and tachycardia.
What to do
Monitor ECG and serum potassium, particularly in patients with structural heart disease or electrolyte disturbance; use the recommended olodaterol dose only.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Dronedarone with Olodaterol inhaled?
MediHelp rates the interaction as moderate. Dronedarone and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone prolongs the QT interval and olodaterol, a long-acting beta2 agonist, can cause tachycardia, hypokalemia and QTc effects. Together they may raise the risk of ventricular arrhythmias, although systemic olodaterol exposure from inhalation is low.
How serious is the interaction between Dronedarone and Olodaterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and serum potassium, particularly in patients with structural heart disease or electrolyte disturbance; use the recommended olodaterol dose only.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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