Drug interactions
Dronedarone + Romidepsin
Severity: Major
Dronedarone and Romidepsin: major interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone may raise romidepsin concentrations through CYP3A4 and P-glycoprotein inhibition, and both drugs affect cardiac repolarization. This combination increases the risk of QT prolongation and arrhythmia as well as romidepsin toxicity such as myelosuppression and nausea.
What this interaction means in plain words
Dronedarone and Romidepsin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Dronedarone inhibits CYP3A4 and P-glycoprotein, raising romidepsin exposure, with additive QTc prolongation.
What to do
Avoid if possible; otherwise monitor ECG, potassium and magnesium closely and watch for romidepsin toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Dronedarone with Romidepsin?
MediHelp rates the interaction as major. Dronedarone and Romidepsin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dronedarone may raise romidepsin concentrations through CYP3A4 and P-glycoprotein inhibition, and both drugs affect cardiac repolarization. This combination increases the risk of QT prolongation and arrhythmia as well as romidepsin toxicity such as myelosuppression and nausea.
How serious is the interaction between Dronedarone and Romidepsin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise monitor ECG, potassium and magnesium closely and watch for romidepsin toxicity.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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