Drug interactions
Dronedarone + Saquinavir
Severity: Contraindicated
Dronedarone and Saquinavir: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Saquinavir, given with ritonavir, strongly inhibits CYP3A4 and raises dronedarone concentrations. Saquinavir itself also prolongs QT, so arrhythmia risk is compounded.
What this interaction means in plain words
Dronedarone and Saquinavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
CYP3A4 inhibition reduces dronedarone clearance, plus additive QT prolongation.
What to do
Avoid the combination; use an alternative antiretroviral or antiarrhythmic.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Dronedarone with Saquinavir?
MediHelp rates the interaction as contraindicated. Dronedarone and Saquinavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Saquinavir, given with ritonavir, strongly inhibits CYP3A4 and raises dronedarone concentrations. Saquinavir itself also prolongs QT, so arrhythmia risk is compounded.
How serious is the interaction between Dronedarone and Saquinavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use an alternative antiretroviral or antiarrhythmic.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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