Drug interactions
Dronedarone + Selumetinib
Severity: Moderate
Dronedarone and Selumetinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selumetinib is metabolized mainly by CYP3A4, and dronedarone as a moderate inhibitor can increase its exposure. This may increase selumetinib toxicities such as gastrointestinal effects, rash and cardiomyopathy.
What this interaction means in plain words
Dronedarone and Selumetinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronedarone belongs to Cardiovascular; Selumetinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4 reduces selumetinib clearance.
What to do
Avoid if possible; otherwise reduce the selumetinib dose per labeling for moderate CYP3A inhibitors and monitor for adverse reactions.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Selumetinib
Frequently asked questions
Can I take Dronedarone with Selumetinib?
MediHelp rates the interaction as moderate. Dronedarone and Selumetinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selumetinib is metabolized mainly by CYP3A4, and dronedarone as a moderate inhibitor can increase its exposure. This may increase selumetinib toxicities such as gastrointestinal effects, rash and cardiomyopathy.
How serious is the interaction between Dronedarone and Selumetinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise reduce the selumetinib dose per labeling for moderate CYP3A inhibitors and monitor for adverse reactions.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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