Drug interactions
Dronedarone + Sildenafil
Severity: Moderate
Dronedarone and Sildenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone is a moderate CYP3A4 inhibitor and can raise sildenafil concentrations. This increases the risk of hypotension and other dose-related adverse effects of sildenafil.
What this interaction means in plain words
Dronedarone and Sildenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronedarone belongs to Cardiovascular; Sildenafil belongs to Genitourinary.
Why it happens
Dronedarone inhibits CYP3A4, decreasing the metabolism of sildenafil.
What to do
Use a reduced starting dose of sildenafil, such as 25 mg, and monitor blood pressure and adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sildenafil
- Amyl nitrite + Sildenafil Contraindicated
- Atazanavir + Sildenafil Contraindicated
- Cobicistat + Sildenafil Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Sildenafil Contraindicated
- Glyceryl trinitrate pr + Sildenafil Contraindicated
- Isosorbide dinitrate + Sildenafil Contraindicated
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Dronedarone with Sildenafil?
MediHelp rates the interaction as moderate. Dronedarone and Sildenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone is a moderate CYP3A4 inhibitor and can raise sildenafil concentrations. This increases the risk of hypotension and other dose-related adverse effects of sildenafil.
How serious is the interaction between Dronedarone and Sildenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a reduced starting dose of sildenafil, such as 25 mg, and monitor blood pressure and adverse effects.
What other medicines interact with Sildenafil?
MediHelp also lists interactions of Sildenafil with, for example, Amyl nitrite, Atazanavir, Cobicistat. The full list is on the Sildenafil page.
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