Drug interactions
Dronedarone + Sufentanil sl
Severity: Major
Dronedarone and Sufentanil sl: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone may raise sufentanil concentrations, which could increase and prolong opioid effects including sedation and potentially fatal respiratory depression. Dronedarone's bradycardic effects may also add to opioid-related bradycardia.
What this interaction means in plain words
Dronedarone and Sufentanil sl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Dronedarone inhibits CYP3A4, reducing the clearance of sufentanil.
What to do
Monitor closely for respiratory depression and sedation, particularly at the start of therapy or when dronedarone is added; reduce the sufentanil dose or use an alternative analgesic if needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
- Dronedarone 400 mg film-coated tablets - SmPC sections 4.3/4.5 (class statement: substrates of P-glycoproteins, CYP 3A4 or CYP 2D6; "Dronedarone has therefore, the potential to interact on medicinal products substrates of P-glycoproteins, CYP 3A4 or CYP 2D6.") — electronic medicines compendium (UK SmPC)
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Dronedarone with Sufentanil sl?
MediHelp rates the interaction as major. Dronedarone and Sufentanil sl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dronedarone may raise sufentanil concentrations, which could increase and prolong opioid effects including sedation and potentially fatal respiratory depression. Dronedarone's bradycardic effects may also add to opioid-related bradycardia.
How serious is the interaction between Dronedarone and Sufentanil sl?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for respiratory depression and sedation, particularly at the start of therapy or when dronedarone is added; reduce the sufentanil dose or use an alternative analgesic if needed.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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