Drug interactions
Dronedarone + Teniposide
Severity: Moderate
Dronedarone and Teniposide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone may increase teniposide exposure through P-glycoprotein inhibition, possibly worsening myelosuppression and mucositis. The magnitude is not well defined.
What this interaction means in plain words
Dronedarone and Teniposide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Dronedarone inhibits P-glycoprotein efflux of teniposide.
What to do
Monitor blood counts and signs of toxicity, and reduce the teniposide dose if marked toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Dronedarone with Teniposide?
MediHelp rates the interaction as moderate. Dronedarone and Teniposide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone may increase teniposide exposure through P-glycoprotein inhibition, possibly worsening myelosuppression and mucositis. The magnitude is not well defined.
How serious is the interaction between Dronedarone and Teniposide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and signs of toxicity, and reduce the teniposide dose if marked toxicity occurs.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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