Drug interactions
Dronedarone + Tezacaftor
Severity: Moderate
Dronedarone and Tezacaftor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone can increase tezacaftor exposure by inhibiting CYP3A4. This may increase adverse effects of the tezacaftor combination product.
What this interaction means in plain words
Dronedarone and Tezacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated metabolism of tezacaftor.
What to do
Adjust the dosing schedule of the tezacaftor-containing product per its labeling for moderate CYP3A inhibitors. Monitor for adverse effects and liver enzymes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Dronedarone with Tezacaftor?
MediHelp rates the interaction as moderate. Dronedarone and Tezacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone can increase tezacaftor exposure by inhibiting CYP3A4. This may increase adverse effects of the tezacaftor combination product.
How serious is the interaction between Dronedarone and Tezacaftor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Adjust the dosing schedule of the tezacaftor-containing product per its labeling for moderate CYP3A inhibitors. Monitor for adverse effects and liver enzymes.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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