Drug interactions
Dronedarone + Theophylline
Severity: Moderate
Dronedarone and Theophylline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone inhibits CYP3A4 and might modestly raise theophylline concentrations. The effect is expected to be limited since theophylline is mostly cleared by CYP1A2.
What this interaction means in plain words
Dronedarone and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronedarone belongs to Cardiovascular; Theophylline belongs to Respiratory.
Why it happens
Dronedarone inhibits CYP3A4, a minor theophylline metabolic pathway.
What to do
Monitor theophylline levels and signs of toxicity after starting dronedarone.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Theophylline
- Riociguat + Theophylline Contraindicated
- Adenosine + Theophylline Major
- Apalutamide + Theophylline Major
- Bupropion + Theophylline Major
- Carvedilol + Theophylline Major
- Cimetidine + Theophylline Major
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Dronedarone with Theophylline?
MediHelp rates the interaction as moderate. Dronedarone and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone inhibits CYP3A4 and might modestly raise theophylline concentrations. The effect is expected to be limited since theophylline is mostly cleared by CYP1A2.
How serious is the interaction between Dronedarone and Theophylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor theophylline levels and signs of toxicity after starting dronedarone.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
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