Drug interactions
Dronedarone + Triazolam
Severity: Moderate
Dronedarone and Triazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone can increase triazolam levels because triazolam is a sensitive CYP3A4 substrate. This may cause excessive sedation, psychomotor impairment and respiratory depression.
What this interaction means in plain words
Dronedarone and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Dronedarone inhibits CYP3A4, reducing the first-pass and systemic metabolism of triazolam.
What to do
Use a lower triazolam starting dose and monitor for oversedation, or switch to a benzodiazepine not cleared by CYP3A4 such as temazepam.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Dronedarone with Triazolam?
MediHelp rates the interaction as moderate. Dronedarone and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone can increase triazolam levels because triazolam is a sensitive CYP3A4 substrate. This may cause excessive sedation, psychomotor impairment and respiratory depression.
How serious is the interaction between Dronedarone and Triazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a lower triazolam starting dose and monitor for oversedation, or switch to a benzodiazepine not cleared by CYP3A4 such as temazepam.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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