Drug interactions
Dronedarone + Vilanterol / fluticasone furoate inhaled
Severity: Moderate
Dronedarone and Vilanterol / fluticasone furoate inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol is a beta-agonist that may prolong the QT interval and increase heart rate, which could add to the arrhythmic risk of dronedarone. Systemic exposure from inhalation is low, so the effect is usually modest.
What this interaction means in plain words
Dronedarone and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on cardiac repolarization and sympathomimetic cardiac stimulation.
What to do
Use at the lowest effective dose and monitor ECG and heart rate in patients with other QT risk factors. Correct hypokalemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Dronedarone with Vilanterol / fluticasone furoate inhaled?
MediHelp rates the interaction as moderate. Dronedarone and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilanterol is a beta-agonist that may prolong the QT interval and increase heart rate, which could add to the arrhythmic risk of dronedarone. Systemic exposure from inhalation is low, so the effect is usually modest.
How serious is the interaction between Dronedarone and Vilanterol / fluticasone furoate inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use at the lowest effective dose and monitor ECG and heart rate in patients with other QT risk factors. Correct hypokalemia.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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