Drug interactions
Dronedarone + Zaleplon
Severity: Minor
Dronedarone and Zaleplon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone may increase zaleplon levels through CYP3A4 inhibition, although zaleplon is mainly cleared by aldehyde oxidase. Increased sedation and psychomotor impairment are possible.
What this interaction means in plain words
Dronedarone and Zaleplon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dronedarone belongs to Cardiovascular; Zaleplon belongs to Central Nervous System.
Why it happens
Dronedarone inhibits the secondary CYP3A4 pathway of zaleplon metabolism.
What to do
Use the lowest effective zaleplon dose and counsel about next-day drowsiness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Zaleplon
- Calcium / magnesium / potassium / sodium oxybates + Zaleplon Contraindicated
- Sodium oxybate + Zaleplon Contraindicated
- Brexanolone + Zaleplon Major
- Buprenorphine long-acting + Zaleplon Major
- Buprenorphine subdermal implant + Zaleplon Major
- Buprenorphine transdermal + Zaleplon Major
Frequently asked questions
Can I take Dronedarone with Zaleplon?
MediHelp rates the interaction as minor. Dronedarone and Zaleplon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dronedarone may increase zaleplon levels through CYP3A4 inhibition, although zaleplon is mainly cleared by aldehyde oxidase. Increased sedation and psychomotor impairment are possible.
How serious is the interaction between Dronedarone and Zaleplon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective zaleplon dose and counsel about next-day drowsiness.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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