Drug interactions
Dronedarone + Zanubrutinib
Severity: Moderate
Dronedarone and Zanubrutinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone raises zanubrutinib exposure by inhibiting CYP3A4, which may increase toxicities such as bleeding, cytopenias and atrial fibrillation or other arrhythmias.
What this interaction means in plain words
Dronedarone and Zanubrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronedarone belongs to Cardiovascular; Zanubrutinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated metabolism of zanubrutinib.
What to do
Reduce zanubrutinib to 80 mg twice daily during coadministration. Monitor blood counts and bleeding and cardiac rhythm.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Zanubrutinib
Frequently asked questions
Can I take Dronedarone with Zanubrutinib?
MediHelp rates the interaction as moderate. Dronedarone and Zanubrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone raises zanubrutinib exposure by inhibiting CYP3A4, which may increase toxicities such as bleeding, cytopenias and atrial fibrillation or other arrhythmias.
How serious is the interaction between Dronedarone and Zanubrutinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce zanubrutinib to 80 mg twice daily during coadministration. Monitor blood counts and bleeding and cardiac rhythm.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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