Drug interactions
Dronedarone + Zolpidem
Severity: Minor
Dronedarone and Zolpidem: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone, a moderate CYP3A4 inhibitor, may increase zolpidem exposure. This can lead to greater sedation, dizziness and next-day psychomotor impairment.
What this interaction means in plain words
Dronedarone and Zolpidem have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dronedarone belongs to Cardiovascular; Zolpidem belongs to Central Nervous System.
Why it happens
Dronedarone inhibits CYP3A4-mediated metabolism of zolpidem.
What to do
Start with the lowest zolpidem dose and warn about next-day impairment. Reduce the dose if excessive sedation occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Zolpidem
Frequently asked questions
Can I take Dronedarone with Zolpidem?
MediHelp rates the interaction as minor. Dronedarone and Zolpidem have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dronedarone, a moderate CYP3A4 inhibitor, may increase zolpidem exposure. This can lead to greater sedation, dizziness and next-day psychomotor impairment.
How serious is the interaction between Dronedarone and Zolpidem?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the lowest zolpidem dose and warn about next-day impairment. Reduce the dose if excessive sedation occurs.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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