Drug interactions
Droperidol + Midazolam
Severity: Moderate
Droperidol and Midazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Droperidol and midazolam are often used together perioperatively, but the combination produces additive sedation and may cause hypotension or respiratory depression. Droperidol also carries QT-prolongation risk independent of midazolam.
What this interaction means in plain words
Droperidol and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from dopamine antagonism and GABA-A potentiation.
What to do
Titrate each drug cautiously and monitor sedation, blood pressure, oxygenation and ECG. Reduce doses in elderly or debilitated patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Frequently asked questions
Can I take Droperidol with Midazolam?
MediHelp rates the interaction as moderate. Droperidol and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Droperidol and midazolam are often used together perioperatively, but the combination produces additive sedation and may cause hypotension or respiratory depression. Droperidol also carries QT-prolongation risk independent of midazolam.
How serious is the interaction between Droperidol and Midazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate each drug cautiously and monitor sedation, blood pressure, oxygenation and ECG. Reduce doses in elderly or debilitated patients.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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