Drug interactions
Ibutilide + Moxifloxacin
Severity: Contraindicated
Ibutilide and Moxifloxacin: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibutilide strongly prolongs repolarization and carries a substantial risk of torsades de pointes. Adding moxifloxacin further increases QT prolongation and arrhythmia risk.
What this interaction means in plain words
Ibutilide and Moxifloxacin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ibutilide belongs to Cardiovascular; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Additive potassium channel blockade leading to delayed ventricular repolarization.
What to do
Do not coadminister; use an alternative antibacterial while ibutilide is being used. Correct hypokalemia and hypomagnesemia and monitor ECG if exposure has occurred.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Other interactions of Ibutilide
- Amiodarone + Ibutilide Contraindicated
- Amisulpride + Ibutilide Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Clarithromycin + Ibutilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Dolasetron + Ibutilide Contraindicated
Frequently asked questions
Can I take Ibutilide with Moxifloxacin?
MediHelp rates the interaction as contraindicated. Ibutilide and Moxifloxacin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ibutilide strongly prolongs repolarization and carries a substantial risk of torsades de pointes. Adding moxifloxacin further increases QT prolongation and arrhythmia risk.
How serious is the interaction between Ibutilide and Moxifloxacin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; use an alternative antibacterial while ibutilide is being used. Correct hypokalemia and hypomagnesemia and monitor ECG if exposure has occurred.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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