Drug interactions
Droperidol + Tacrolimus
Severity: Major
Droperidol and Tacrolimus: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Droperidol has a boxed warning for QT prolongation and torsades de pointes, and tacrolimus can add to this effect. The combination raises the risk of life-threatening arrhythmia.
What this interaction means in plain words
Droperidol and Tacrolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation through effects on cardiac repolarization.
What to do
Avoid this combination and use a non-QT-prolonging antiemetic or sedative instead. If it cannot be avoided, obtain an ECG first and continue monitoring with electrolytes corrected.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Droperidol with Tacrolimus?
MediHelp rates the interaction as major. Droperidol and Tacrolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Droperidol has a boxed warning for QT prolongation and torsades de pointes, and tacrolimus can add to this effect. The combination raises the risk of life-threatening arrhythmia.
How serious is the interaction between Droperidol and Tacrolimus?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid this combination and use a non-QT-prolonging antiemetic or sedative instead. If it cannot be avoided, obtain an ECG first and continue monitoring with electrolytes corrected.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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