Drug interactions
Drospirenone + Dutasteride-tamsulosin
Severity: Minor
Drospirenone and Dutasteride-tamsulosin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone is not a clinically meaningful CYP3A4 inhibitor, so no relevant rise in tamsulosin exposure is expected. Drospirenone is also generally used in women, making co-prescription with this BPH combination unlikely.
What this interaction means in plain words
Drospirenone and Dutasteride-tamsulosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Drospirenone belongs to Endocrine; Dutasteride-tamsulosin belongs to Genitourinary.
Why it happens
No established mechanism; drospirenone has only weak CYP3A4 inhibitory potential.
What to do
No action is required beyond routine monitoring for tamsulosin-related orthostatic symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dutasteride-tamsulosin
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Dutasteride-tamsulosin?
MediHelp rates the interaction as minor. Drospirenone and Dutasteride-tamsulosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Drospirenone is not a clinically meaningful CYP3A4 inhibitor, so no relevant rise in tamsulosin exposure is expected. Drospirenone is also generally used in women, making co-prescription with this BPH combination unlikely.
How serious is the interaction between Drospirenone and Dutasteride-tamsulosin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is required beyond routine monitoring for tamsulosin-related orthostatic symptoms.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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