Drug interactions
Drospirenone + Enalapril-hydrochlorothiazide
Severity: Moderate
Drospirenone and Enalapril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has antimineralocorticoid activity and can raise serum potassium, which adds to the hyperkalemia risk from enalapril. Hydrochlorothiazide partly offsets this, but the net effect is unpredictable, particularly in renal impairment.
What this interaction means in plain words
Drospirenone and Enalapril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Drospirenone belongs to Endocrine; Enalapril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive potassium retention from aldosterone antagonism by drospirenone and reduced aldosterone from ACE inhibition, partly opposed by thiazide potassium loss.
What to do
Check serum potassium during the first cycle of treatment and periodically thereafter. Avoid in patients with renal impairment or other hyperkalemia risks.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Drospirenone and Enalapril-hydrochlorothiazide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Enalapril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Drospirenone and Enalapril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone has antimineralocorticoid activity and can raise serum potassium, which adds to the hyperkalemia risk from enalapril. Hydrochlorothiazide partly offsets this, but the net effect is unpredictable, particularly in renal impairment.
How serious is the interaction between Drospirenone and Enalapril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium during the first cycle of treatment and periodically thereafter. Avoid in patients with renal impairment or other hyperkalemia risks.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
