Drug interactions
Drospirenone + Etodolac
Severity: Moderate
Drospirenone and Etodolac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has anti-mineralocorticoid activity and can raise potassium, and NSAIDs can add to this effect. The risk of hyperkalemia is mainly relevant in patients with renal impairment or on other potassium-raising drugs.
What this interaction means in plain words
Drospirenone and Etodolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Drospirenone belongs to Endocrine; Etodolac belongs to Musculoskeletal.
Why it happens
Drospirenone aldosterone antagonism combined with NSAID-reduced renal potassium excretion.
What to do
In patients on long-term daily NSAIDs, check serum potassium during the first cycle. Avoid in renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Drospirenone and Etodolac, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Etodolac?
MediHelp rates the interaction as moderate. Drospirenone and Etodolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone has anti-mineralocorticoid activity and can raise potassium, and NSAIDs can add to this effect. The risk of hyperkalemia is mainly relevant in patients with renal impairment or on other potassium-raising drugs.
How serious is the interaction between Drospirenone and Etodolac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: In patients on long-term daily NSAIDs, check serum potassium during the first cycle. Avoid in renal impairment.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
