Drug interactions
Drospirenone + Hydrochlorothiazide-losartan
Severity: Moderate
Drospirenone and Hydrochlorothiazide-losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has anti-mineralocorticoid activity and raises potassium, as does losartan. Together they may cause hyperkalemia, although the hydrochlorothiazide component lowers potassium and partly offsets the risk.
What this interaction means in plain words
Drospirenone and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Drospirenone belongs to Endocrine; Hydrochlorothiazide-losartan belongs to Cardiovascular.
Why it happens
Additive potassium retention from angiotensin receptor blockade and the anti-aldosterone effect of drospirenone.
What to do
Measure serum potassium during the first treatment cycle, particularly in patients with renal impairment or other potassium-raising drugs. Choose a different contraceptive if potassium rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as moderate. Drospirenone and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone has anti-mineralocorticoid activity and raises potassium, as does losartan. Together they may cause hyperkalemia, although the hydrochlorothiazide component lowers potassium and partly offsets the risk.
How serious is the interaction between Drospirenone and Hydrochlorothiazide-losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure serum potassium during the first treatment cycle, particularly in patients with renal impairment or other potassium-raising drugs. Choose a different contraceptive if potassium rises.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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