Drug interactions
Drospirenone + Irbesartan
Severity: Moderate
Drospirenone and Irbesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has antimineralocorticoid activity and can raise serum potassium, and irbesartan also reduces potassium excretion. Together they may cause hyperkalemia, especially with renal impairment.
What this interaction means in plain words
Drospirenone and Irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Drospirenone belongs to Endocrine; Irbesartan belongs to Cardiovascular.
Why it happens
Additive potassium retention through angiotensin receptor blockade and drospirenone's aldosterone antagonism.
What to do
Check serum potassium during the first cycle and periodically thereafter. Avoid in patients with renal impairment or other hyperkalemia risks.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Irbesartan?
MediHelp rates the interaction as moderate. Drospirenone and Irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone has antimineralocorticoid activity and can raise serum potassium, and irbesartan also reduces potassium excretion. Together they may cause hyperkalemia, especially with renal impairment.
How serious is the interaction between Drospirenone and Irbesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium during the first cycle and periodically thereafter. Avoid in patients with renal impairment or other hyperkalemia risks.
What other medicines interact with Irbesartan?
MediHelp also lists interactions of Irbesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Irbesartan page.
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