Drug interactions
Drospirenone + Isavuconazonium
Severity: Moderate
Drospirenone and Isavuconazonium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole is a moderate CYP3A4 inhibitor and may modestly increase drospirenone exposure. Drospirenone has antimineralocorticoid effects, so higher levels may raise potassium.
What this interaction means in plain words
Drospirenone and Isavuconazonium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Drospirenone belongs to Endocrine; Isavuconazonium belongs to Anti Fungals.
Why it happens
Isavuconazole inhibits CYP3A4, reducing drospirenone clearance.
What to do
Monitor serum potassium if risk factors for hyperkalemia exist; no routine dose change is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Drospirenone
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Drospirenone with Isavuconazonium?
MediHelp rates the interaction as moderate. Drospirenone and Isavuconazonium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isavuconazole is a moderate CYP3A4 inhibitor and may modestly increase drospirenone exposure. Drospirenone has antimineralocorticoid effects, so higher levels may raise potassium.
How serious is the interaction between Drospirenone and Isavuconazonium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium if risk factors for hyperkalemia exist; no routine dose change is needed.
What other medicines interact with Drospirenone?
MediHelp also lists interactions of Drospirenone with, for example, Belzutifan, Bosentan, Carbamazepine. The full list is on the Drospirenone page.
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