Drug interactions
Drospirenone + Ketoprofen
Severity: Moderate
Drospirenone and Ketoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has antimineralocorticoid activity and can raise potassium, and NSAIDs can add to this by reducing renal potassium excretion. Risk is mainly in patients with renal, hepatic or adrenal impairment, or on other potassium-raising drugs.
What this interaction means in plain words
Drospirenone and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Drospirenone belongs to Endocrine; Ketoprofen belongs to Musculoskeletal.
Why it happens
Additive hyperkalemic effect from aldosterone antagonism by drospirenone and NSAID suppression of renin-aldosterone and renal prostaglandins.
What to do
In long-term NSAID users, check serum potassium during the first treatment cycle; avoid in renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Ketoprofen?
MediHelp rates the interaction as moderate. Drospirenone and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone has antimineralocorticoid activity and can raise potassium, and NSAIDs can add to this by reducing renal potassium excretion. Risk is mainly in patients with renal, hepatic or adrenal impairment, or on other potassium-raising drugs.
How serious is the interaction between Drospirenone and Ketoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: In long-term NSAID users, check serum potassium during the first treatment cycle; avoid in renal impairment.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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