Drug interactions
Drospirenone + Linagliptin-metformin
Severity: Minor
Drospirenone and Linagliptin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone-containing contraceptives may have a small effect on glucose tolerance, potentially reducing metformin's effect. Drospirenone also has anti-mineralocorticoid effects but this is not relevant to metformin.
What this interaction means in plain words
Drospirenone and Linagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Drospirenone belongs to Endocrine; Linagliptin-metformin belongs to Endocrine.
Why it happens
Progestogen-related mild reduction in insulin sensitivity opposing metformin action.
What to do
Monitor glucose or HbA1c after initiation and adjust antidiabetic therapy if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Linagliptin-metformin
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Linagliptin-metformin?
MediHelp rates the interaction as minor. Drospirenone and Linagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Drospirenone-containing contraceptives may have a small effect on glucose tolerance, potentially reducing metformin's effect. Drospirenone also has anti-mineralocorticoid effects but this is not relevant to metformin.
How serious is the interaction between Drospirenone and Linagliptin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose or HbA1c after initiation and adjust antidiabetic therapy if needed.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
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