Drug interactions
Drospirenone + Metaxalone
Severity: Minor
Drospirenone and Metaxalone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has little inhibitory effect on CYP3A4 at clinical doses, and metaxalone is cleared by several pathways. A clinically important increase in metaxalone exposure is not expected.
What this interaction means in plain words
Drospirenone and Metaxalone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Drospirenone belongs to Endocrine; Metaxalone belongs to Musculoskeletal.
Why it happens
Weak theoretical inhibition of CYP3A4; no established clinical effect.
What to do
No dose change is needed. Routine awareness of metaxalone sedation is sufficient.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metaxalone
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Metaxalone?
MediHelp rates the interaction as minor. Drospirenone and Metaxalone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Drospirenone has little inhibitory effect on CYP3A4 at clinical doses, and metaxalone is cleared by several pathways. A clinically important increase in metaxalone exposure is not expected.
How serious is the interaction between Drospirenone and Metaxalone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Routine awareness of metaxalone sedation is sufficient.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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