Drug interactions
Drospirenone + Nebivolol
Severity: Minor
Drospirenone and Nebivolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has anti-mineralocorticoid activity and can raise serum potassium, and beta-blockers may slightly impair cellular potassium uptake. Clinically significant hyperkalemia is uncommon in patients with normal renal function.
What this interaction means in plain words
Drospirenone and Nebivolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Drospirenone belongs to Endocrine; Nebivolol belongs to Cardiovascular.
Why it happens
Reduced renal potassium excretion from drospirenone with mild impairment of cellular potassium uptake from beta-blockade.
What to do
Check serum potassium in patients with renal impairment or other potassium-raising drugs, otherwise no change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Nebivolol?
MediHelp rates the interaction as minor. Drospirenone and Nebivolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Drospirenone has anti-mineralocorticoid activity and can raise serum potassium, and beta-blockers may slightly impair cellular potassium uptake. Clinically significant hyperkalemia is uncommon in patients with normal renal function.
How serious is the interaction between Drospirenone and Nebivolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium in patients with renal impairment or other potassium-raising drugs, otherwise no change is needed.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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