Drug interactions
Drospirenone + Nicardipine
Severity: Minor
Drospirenone and Nicardipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone is metabolized partly by CYP3A4 and does not significantly inhibit it. Nicardipine may slightly raise drospirenone exposure, but drospirenone's potassium-sparing effect is the more relevant concern with other agents, not nicardipine.
What this interaction means in plain words
Drospirenone and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Drospirenone belongs to Endocrine; Nicardipine belongs to Cardiovascular.
Why it happens
Weak CYP3A4 inhibition by nicardipine may modestly raise drospirenone levels.
What to do
No adjustment is required. Check serum potassium if other potassium-raising drugs are also used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nicardipine
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Nicardipine?
MediHelp rates the interaction as minor. Drospirenone and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Drospirenone is metabolized partly by CYP3A4 and does not significantly inhibit it. Nicardipine may slightly raise drospirenone exposure, but drospirenone's potassium-sparing effect is the more relevant concern with other agents, not nicardipine.
How serious is the interaction between Drospirenone and Nicardipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is required. Check serum potassium if other potassium-raising drugs are also used.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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