Drug interactions
Drospirenone + Quinidine
Severity: Minor
Drospirenone and Quinidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone is not a clinically significant CYP3A4 inhibitor, so it is unlikely to raise quinidine levels. Drospirenone can raise potassium, and hyperkalemia or electrolyte shifts may affect quinidine's cardiac effects.
What this interaction means in plain words
Drospirenone and Quinidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Drospirenone belongs to Endocrine; Quinidine belongs to Anti Parasitic.
Why it happens
Minimal CYP3A4 effect; potassium-sparing action of drospirenone may alter cardiac sensitivity.
What to do
Check potassium if risk factors for hyperkalemia exist and monitor ECG per usual quinidine practice.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Quinidine?
MediHelp rates the interaction as minor. Drospirenone and Quinidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Drospirenone is not a clinically significant CYP3A4 inhibitor, so it is unlikely to raise quinidine levels. Drospirenone can raise potassium, and hyperkalemia or electrolyte shifts may affect quinidine's cardiac effects.
How serious is the interaction between Drospirenone and Quinidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium if risk factors for hyperkalemia exist and monitor ECG per usual quinidine practice.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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