Drug interactions
Drospirenone + Sparsentan
Severity: Moderate
Drospirenone and Sparsentan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sparsentan can raise serum potassium, and drospirenone has anti-mineralocorticoid properties that also raise potassium. Together they increase the risk of hyperkalemia. Sparsentan also carries a teratogenicity warning that affects contraceptive planning.
What this interaction means in plain words
Drospirenone and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Drospirenone belongs to Endocrine; Sparsentan belongs to Genitourinary.
Why it happens
Additive hyperkalemia from reduced renal potassium excretion.
What to do
Monitor serum potassium frequently, especially at initiation. Consider a contraceptive without anti-mineralocorticoid effect if hyperkalemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Drospirenone
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Drospirenone with Sparsentan?
MediHelp rates the interaction as moderate. Drospirenone and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sparsentan can raise serum potassium, and drospirenone has anti-mineralocorticoid properties that also raise potassium. Together they increase the risk of hyperkalemia. Sparsentan also carries a teratogenicity warning that affects contraceptive planning.
How serious is the interaction between Drospirenone and Sparsentan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium frequently, especially at initiation. Consider a contraceptive without anti-mineralocorticoid effect if hyperkalemia occurs.
What other medicines interact with Drospirenone?
MediHelp also lists interactions of Drospirenone with, for example, Belzutifan, Bosentan, Carbamazepine. The full list is on the Drospirenone page.
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