Drug interactions
Drospirenone + Sulindac
Severity: Moderate
Drospirenone and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has antimineralocorticoid activity and can raise serum potassium. NSAIDs reduce renin and aldosterone through lowered prostaglandin synthesis and may impair renal potassium excretion, so hyperkalemia is possible, particularly in patients with renal impairment.
What this interaction means in plain words
Drospirenone and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Drospirenone belongs to Endocrine; Sulindac belongs to Musculoskeletal.
Why it happens
Additive hyperkalemic effects: aldosterone antagonism by drospirenone plus NSAID-induced suppression of the renin-aldosterone axis and reduced renal perfusion.
What to do
Check serum potassium during the first cycle of concurrent long-term use, especially in patients with renal impairment or on other potassium-raising drugs. Stop or change therapy if potassium rises significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Sulindac?
MediHelp rates the interaction as moderate. Drospirenone and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone has antimineralocorticoid activity and can raise serum potassium. NSAIDs reduce renin and aldosterone through lowered prostaglandin synthesis and may impair renal potassium excretion, so hyperkalemia is possible, particularly in patients with renal impairment.
How serious is the interaction between Drospirenone and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium during the first cycle of concurrent long-term use, especially in patients with renal impairment or on other potassium-raising drugs. Stop or change therapy if potassium rises significantly.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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