Drug interactions
Drospirenone + Sulphasalazine
Severity: Minor
Drospirenone and Sulphasalazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has antimineralocorticoid activity and can raise potassium. Sulfasalazine has no established potassium-raising effect, so the combination adds little beyond drospirenone's own risk.
What this interaction means in plain words
Drospirenone and Sulphasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Drospirenone belongs to Endocrine; Sulphasalazine belongs to Gastrointestinal Tract.
Why it happens
No established mechanism; hyperkalemia risk arises from drospirenone's antimineralocorticoid action.
What to do
Monitor potassium only if other risk factors such as renal impairment or other potassium-raising drugs are present.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sulphasalazine
- Deferiprone + Sulphasalazine Major
- Pexidartinib + Sulphasalazine Major
- Sepiapterin + Sulphasalazine Major
- Acalabrutinib + Sulphasalazine Moderate
- Aceclofenac + Sulphasalazine Moderate
- Asciminib + Sulphasalazine Moderate
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Sulphasalazine?
MediHelp rates the interaction as minor. Drospirenone and Sulphasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Drospirenone has antimineralocorticoid activity and can raise potassium. Sulfasalazine has no established potassium-raising effect, so the combination adds little beyond drospirenone's own risk.
How serious is the interaction between Drospirenone and Sulphasalazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor potassium only if other risk factors such as renal impairment or other potassium-raising drugs are present.
What other medicines interact with Sulphasalazine?
MediHelp also lists interactions of Sulphasalazine with, for example, Deferiprone, Pexidartinib, Sepiapterin. The full list is on the Sulphasalazine page.
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