Drug interactions
Drospirenone + Voclosporin
Severity: Moderate
Drospirenone and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has anti-mineralocorticoid activity and can raise serum potassium, and voclosporin, a calcineurin inhibitor, also causes hyperkalemia. Used together they can produce additive potassium elevation, particularly in patients with reduced renal function, which is common in lupus nephritis.
What this interaction means in plain words
Drospirenone and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Drospirenone belongs to Endocrine; Voclosporin belongs to Miscellaneous.
Why it happens
Additive pharmacodynamic hyperkalemia from aldosterone antagonism by drospirenone and reduced renal potassium excretion by calcineurin inhibition.
What to do
Check serum potassium and renal function before starting and periodically during combined use. Consider a different contraceptive without anti-mineralocorticoid activity if potassium rises or renal impairment is present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Drospirenone
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Drospirenone with Voclosporin?
MediHelp rates the interaction as moderate. Drospirenone and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone has anti-mineralocorticoid activity and can raise serum potassium, and voclosporin, a calcineurin inhibitor, also causes hyperkalemia. Used together they can produce additive potassium elevation, particularly in patients with reduced renal function, which is common in lupus nephritis.
How serious is the interaction between Drospirenone and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and renal function before starting and periodically during combined use. Consider a different contraceptive without anti-mineralocorticoid activity if potassium rises or renal impairment is present.
What other medicines interact with Drospirenone?
MediHelp also lists interactions of Drospirenone with, for example, Belzutifan, Bosentan, Carbamazepine. The full list is on the Drospirenone page.
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