Drug interactions
Droxidopa + Frovatriptan
Severity: Moderate
Droxidopa and Frovatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Droxidopa is converted to norepinephrine and can raise blood pressure, particularly when supine. Frovatriptan causes vasoconstriction and can also raise blood pressure, so combined use may worsen hypertension.
What this interaction means in plain words
Droxidopa and Frovatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Droxidopa belongs to Cardiovascular; Frovatriptan belongs to Central Nervous System.
Why it happens
Additive pressor effects from norepinephrine formation and triptan-induced vasoconstriction.
What to do
Monitor blood pressure, including supine readings, when the combination is used. Reduce or stop droxidopa if supine hypertension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Frovatriptan
- Almotriptan + Frovatriptan Contraindicated
- Dihydroergotamine intranasal + Frovatriptan Contraindicated
- Dihydroergotamine + Frovatriptan Contraindicated
- Eletriptan + Frovatriptan Contraindicated
- Ergoloid mesylates + Frovatriptan Contraindicated
- Ergotamine + Frovatriptan Contraindicated
Other interactions of Droxidopa
- Droxidopa + Lisdexamfetamine Major
- Droxidopa + Methamphetamine Major
- Droxidopa + Pseudoephedrine Major
- Adrenaline-articaine + Droxidopa Moderate
- Almotriptan + Droxidopa Moderate
- Caffeine + Droxidopa Moderate
Frequently asked questions
Can I take Droxidopa with Frovatriptan?
MediHelp rates the interaction as moderate. Droxidopa and Frovatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Droxidopa is converted to norepinephrine and can raise blood pressure, particularly when supine. Frovatriptan causes vasoconstriction and can also raise blood pressure, so combined use may worsen hypertension.
How serious is the interaction between Droxidopa and Frovatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, including supine readings, when the combination is used. Reduce or stop droxidopa if supine hypertension develops.
What other medicines interact with Frovatriptan?
MediHelp also lists interactions of Frovatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Frovatriptan page.
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