Drug interactions
Dulaglutide + Insulin degludec
Severity: Moderate
Dulaglutide and Insulin degludec: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dulaglutide with insulin enhances glucose lowering and raises the risk of hypoglycemia. The combination is used therapeutically but typically needs an insulin dose reduction.
What this interaction means in plain words
Dulaglutide and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dulaglutide belongs to Endocrine; Insulin degludec belongs to Endocrine.
Why it happens
GLP-1 receptor agonism increases glucose-dependent insulin secretion and suppresses glucagon, adding to exogenous insulin.
What to do
Monitor blood glucose when starting dulaglutide and consider reducing the insulin degludec dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec
Other interactions of Dulaglutide
Frequently asked questions
Can I take Dulaglutide with Insulin degludec?
MediHelp rates the interaction as moderate. Dulaglutide and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dulaglutide with insulin enhances glucose lowering and raises the risk of hypoglycemia. The combination is used therapeutically but typically needs an insulin dose reduction.
How serious is the interaction between Dulaglutide and Insulin degludec?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting dulaglutide and consider reducing the insulin degludec dose if hypoglycemia occurs.
What other medicines interact with Insulin degludec?
MediHelp also lists interactions of Insulin degludec with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin degludec page.
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