Drug interactions
Dulaglutide + Insulin isophane protamine human
Severity: Moderate
Dulaglutide and Insulin isophane protamine human: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dulaglutide combined with insulin lowers glucose more than either alone and raises the risk of hypoglycemia. The combination is commonly used deliberately but often requires insulin dose reduction.
What this interaction means in plain words
Dulaglutide and Insulin isophane protamine human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dulaglutide belongs to Endocrine; Insulin isophane protamine human belongs to Endocrine.
Why it happens
Additive glucose lowering via glucose-dependent insulin secretion and glucagon suppression from GLP-1 receptor agonism plus exogenous insulin.
What to do
Consider lowering the insulin dose when starting dulaglutide and monitor glucose closely. Titrate insulin according to glucose readings.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin isophane protamine human
- Ethanol + Insulin isophane protamine human Major
- Insulin isophane protamine human + Pioglitazone Major
- Insulin isophane protamine human + Rosiglitazone Major
- Acarbose + Insulin isophane protamine human Moderate
- Albiglutide + Insulin isophane protamine human Moderate
- Alogliptin + Insulin isophane protamine human Moderate
Other interactions of Dulaglutide
Frequently asked questions
Can I take Dulaglutide with Insulin isophane protamine human?
MediHelp rates the interaction as moderate. Dulaglutide and Insulin isophane protamine human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dulaglutide combined with insulin lowers glucose more than either alone and raises the risk of hypoglycemia. The combination is commonly used deliberately but often requires insulin dose reduction.
How serious is the interaction between Dulaglutide and Insulin isophane protamine human?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the insulin dose when starting dulaglutide and monitor glucose closely. Titrate insulin according to glucose readings.
What other medicines interact with Insulin isophane protamine human?
MediHelp also lists interactions of Insulin isophane protamine human with, for example, Ethanol, Pioglitazone, Rosiglitazone. The full list is on the Insulin isophane protamine human page.
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