Drug interactions
Dulaglutide + Nateglinide
Severity: Moderate
Dulaglutide and Nateglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dulaglutide lowers glucose by glucose-dependent insulin secretion, while nateglinide stimulates insulin release independently of glucose. Together they may raise the risk of hypoglycemia. Dulaglutide also slows gastric emptying.
What this interaction means in plain words
Dulaglutide and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dulaglutide belongs to Endocrine; Nateglinide belongs to Endocrine.
Why it happens
Additive pharmacodynamic glucose-lowering effects through insulin secretagogue activity.
What to do
Monitor blood glucose when starting dulaglutide, and consider reducing the nateglinide dose if hypoglycemia occurs. Counsel the patient on hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Other interactions of Dulaglutide
Frequently asked questions
Can I take Dulaglutide with Nateglinide?
MediHelp rates the interaction as moderate. Dulaglutide and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dulaglutide lowers glucose by glucose-dependent insulin secretion, while nateglinide stimulates insulin release independently of glucose. Together they may raise the risk of hypoglycemia. Dulaglutide also slows gastric emptying.
How serious is the interaction between Dulaglutide and Nateglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting dulaglutide, and consider reducing the nateglinide dose if hypoglycemia occurs. Counsel the patient on hypoglycemia symptoms.
What other medicines interact with Nateglinide?
MediHelp also lists interactions of Nateglinide with, for example, Albiglutide, Alogliptin-metformin, Alogliptin-pioglitazone. The full list is on the Nateglinide page.
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