Drug interactions
Dulaglutide + Repaglinide
Severity: Moderate
Dulaglutide and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dulaglutide added to repaglinide increases glucose-dependent insulin release on top of meglitinide stimulation, raising the risk of hypoglycemia. The risk is highest when therapy is started or the dose is escalated.
What this interaction means in plain words
Dulaglutide and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dulaglutide belongs to Endocrine; Repaglinide belongs to Endocrine.
Why it happens
Additive pharmacodynamic effect on insulin secretion.
What to do
Consider lowering the repaglinide dose when starting dulaglutide and monitor blood glucose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporin + Repaglinide Major
- Deferasirox + Repaglinide Major
Other interactions of Dulaglutide
Frequently asked questions
Can I take Dulaglutide with Repaglinide?
MediHelp rates the interaction as moderate. Dulaglutide and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dulaglutide added to repaglinide increases glucose-dependent insulin release on top of meglitinide stimulation, raising the risk of hypoglycemia. The risk is highest when therapy is started or the dose is escalated.
How serious is the interaction between Dulaglutide and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the repaglinide dose when starting dulaglutide and monitor blood glucose.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
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