Drug interactions
Dulaglutide + Somapacitan
Severity: Minor
Dulaglutide and Somapacitan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone analogs can decrease insulin sensitivity and raise blood glucose. This may reduce the glycemic control achieved with dulaglutide in patients with diabetes.
What this interaction means in plain words
Dulaglutide and Somapacitan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dulaglutide belongs to Endocrine; Somapacitan belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism, as growth hormone induces insulin resistance and opposes GLP-1 receptor agonist effects.
What to do
Monitor blood glucose and HbA1c when somapacitan is started or its dose changed. Adjust the antidiabetic regimen if glycemia worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dulaglutide
Other interactions of Somapacitan
- Alogliptin-metformin + Somapacitan Moderate
- Alogliptin-pioglitazone + Somapacitan Moderate
- Alogliptin + Somapacitan Moderate
- Bazedoxifene-conjugated estrogens + Somapacitan Moderate
- Canagliflozin-metformin + Somapacitan Moderate
- Chlorpropamide + Somapacitan Moderate
Frequently asked questions
Can I take Dulaglutide with Somapacitan?
MediHelp rates the interaction as minor. Dulaglutide and Somapacitan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Growth hormone analogs can decrease insulin sensitivity and raise blood glucose. This may reduce the glycemic control achieved with dulaglutide in patients with diabetes.
How serious is the interaction between Dulaglutide and Somapacitan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c when somapacitan is started or its dose changed. Adjust the antidiabetic regimen if glycemia worsens.
What other medicines interact with Dulaglutide?
MediHelp also lists interactions of Dulaglutide with, for example, Insulin degludec-liraglutide, Insulin glargine-lixisenatide, Alogliptin-metformin. The full list is on the Dulaglutide page.
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