Drug interactions
Dutasteride-tamsulosin + Efavirenz
Severity: Moderate
Dutasteride-tamsulosin and Efavirenz: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz is a CYP3A4 inducer, so it is more likely to lower than raise tamsulosin and dutasteride levels. This may reduce their efficacy.
What this interaction means in plain words
Dutasteride-tamsulosin and Efavirenz can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dutasteride-tamsulosin belongs to Genitourinary; Efavirenz belongs to Anti Virals.
Why it happens
Efavirenz induces CYP3A4, increasing metabolism of tamsulosin and dutasteride.
What to do
Monitor urinary symptom control and consider adjusting therapy if the response is reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dutasteride-tamsulosin
Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Dutasteride-tamsulosin with Efavirenz?
MediHelp rates the interaction as moderate. Dutasteride-tamsulosin and Efavirenz can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efavirenz is a CYP3A4 inducer, so it is more likely to lower than raise tamsulosin and dutasteride levels. This may reduce their efficacy.
How serious is the interaction between Dutasteride-tamsulosin and Efavirenz?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor urinary symptom control and consider adjusting therapy if the response is reduced.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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