Drug interactions
Dutasteride-tamsulosin + Imipramine
Severity: Moderate
Dutasteride-tamsulosin and Imipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imipramine is a CYP2D6 substrate and a weak inhibitor of the enzyme, so it may modestly raise tamsulosin exposure. This could increase orthostatic hypotension and dizziness, which tricyclics already promote.
What this interaction means in plain words
Dutasteride-tamsulosin and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dutasteride-tamsulosin belongs to Genitourinary; Imipramine belongs to Central Nervous System.
Why it happens
Competitive inhibition of CYP2D6-mediated tamsulosin metabolism plus additive alpha-blocking and hypotensive effects.
What to do
Monitor for orthostatic hypotension, dizziness and syncope, especially at initiation or dose change. Advise patients to rise slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dutasteride-tamsulosin
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Dutasteride-tamsulosin with Imipramine?
MediHelp rates the interaction as moderate. Dutasteride-tamsulosin and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imipramine is a CYP2D6 substrate and a weak inhibitor of the enzyme, so it may modestly raise tamsulosin exposure. This could increase orthostatic hypotension and dizziness, which tricyclics already promote.
How serious is the interaction between Dutasteride-tamsulosin and Imipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for orthostatic hypotension, dizziness and syncope, especially at initiation or dose change. Advise patients to rise slowly.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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