Drug interactions
Dutasteride-tamsulosin + Istradefylline
Severity: Minor
Dutasteride-tamsulosin and Istradefylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At the 40 mg daily dose, istradefylline weakly inhibits CYP3A4 and can raise exposure to CYP3A4 substrates such as tamsulosin and dutasteride. The effect is not seen at 20 mg daily. A small increase in tamsulosin adverse effects such as dizziness may occur.
What this interaction means in plain words
Dutasteride-tamsulosin and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dutasteride-tamsulosin belongs to Genitourinary; Istradefylline belongs to Central Nervous System.
Why it happens
Istradefylline at higher doses weakly inhibits CYP3A4, reducing substrate clearance.
What to do
Monitor for dizziness and hypotension if istradefylline 40 mg daily is used. Dose changes are rarely needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dutasteride-tamsulosin
Other interactions of Istradefylline
Frequently asked questions
Can I take Dutasteride-tamsulosin with Istradefylline?
MediHelp rates the interaction as minor. Dutasteride-tamsulosin and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. At the 40 mg daily dose, istradefylline weakly inhibits CYP3A4 and can raise exposure to CYP3A4 substrates such as tamsulosin and dutasteride. The effect is not seen at 20 mg daily. A small increase in tamsulosin adverse effects such as dizziness may occur.
How serious is the interaction between Dutasteride-tamsulosin and Istradefylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness and hypotension if istradefylline 40 mg daily is used. Dose changes are rarely needed.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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